Art Robbins Instruments

Liquid Handling Systems for High-Throughput Applications, 
Chemistry, Drug Research, Genomic Solutions and
Protein Crystallography

Please click here to see where we exhibit the systems from Art Robbins Instruments, 
look at some videos about the systems or download directly the Art Robbins Instruments product brochure (PDF)

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“Scorpion”
high-speed single channel pipettor / screen builder

  • Extremely versatile work station can perform anything that can be done with hand-held pipettors, but with the speed, reliability and precision of an automated dispenser
  • High displacement speed gives the opportunity to perform a variety of different liquid handling applications including genomic methods such as PCRs
  • NEW! Nucleic acid normalization as new application for the system with optimized step-by-step software
  • 3 dispense modes: Forward Mode, Sequential Mode, Reverse Mode
  • Compatible with 20 µl, 50 µl, 200 µl and 1000 µl pipette tips with dispensing down to approx. 1 µl
  • Multiple tip sizes can be used in one protocol
  • Suitable pipette tips: see separate price list and below
  • Liquid transfers can be defined as volume, concentration or pH
  • Possibility to set up multiple plates with varying pH, different additives and varying concentration e. g normalization of salt screens
  • The deck has 6 SBS-format plate positions and can accommodate 96 racked 15 ml tubes, deep well blocks, standard 24, 96, 384 and 1536-well plates as well as 96 and 24 well protein crystallization plates, and tip racks
  • Pipette head is designed to reach the bottom of tall tubes such as 15 ml and 50 ml tubes, as well as deep well blocks
  • Re-array screens from 15 ml tubes into 96-well plates
  • Large database of screening reagents contains all standard commercial screens
  • Set up 24-well protein crystallization plates with an optimized screen, and dispense the protein
  • Movement velocity of 2 meters / sec. with extreme accuracy
  • Intelligent motion control software optimizes dispense paths and volumes
  • Liquid level sensing allows the tip to follow liquid levels improving aspirate and dispense accuracies
  • Intuitive software allows for the easy design of
    n-dimension grids and assays
  • Easy set-up of user-defined and gradient screen plates using an innovative graphic software
  • Software graphically shows the content of each well
  • Possibility to import / export csv-files facilitates data transfer and the creation of custom screens
  • Positive air displacement pipette head and a vast reagent database with pre-defined settings make it easy to work with a wide range of fluid viscosities,
    such as 50 % PEG 20,000, 80 % Glycerol and DMSO
  • Environment: 4 °C to 70 °C, non condensing
  • Dimensions: (w x h x d) 48.3 cm x 69.8 cm x 48.3 cm
  • Cat.-No.: 640-1000-10 with desktop computer and multiple software licenses  

Pipette Tips

Pipette tips for the Scorpion for 50 µl, 200 µl and 1000 µl volume options.
Tips are available sterile, non-sterile, with or without filter.
Cat. No.          Description
640-1300-00  1000 µl Pipette Tips, 1536/case
640-1300-01  ∅200 µl Pipette Tips, 2304/case
640-1300-02  0050 µl Pipette Tips, 2304/case

640-1301-00  1000 µl Pipette Tips with Filter, 1536/case, steril
640-1301-01 0∅200 µl Pipette Tips with Filter, 2304/case, steril
 for further information see p.3 of the ARI product range (PDF)

Spring Plate for Low Volume Optimization

Set up complete optimization plates on the Scorpion with the spring fixture. Ideal for setting up the Intelli-Pate 24-4
 (Cat. No.: 102-0004-00) as scale-up optimization plate.

Cat. No.           Description
640-1206-01   Scorpion Low Volume Dispense Platform
 for further information see p.3 of the ARI product range (PDF)

Plate Adapter

Set up optimization directly into a Linbro plate with the Scorpion Linbro Plate Adapter.

Cat. No.            Description
640-1205-01    Scorpion Linbro Plate Pdapter

for further information see p.3 of the ARI product range (PDF)

Racks

Each rack is magnetically keyed to the Scorpion deck to ensure proper alignment.
Cat. No.          Description
640-1099-01  Tube Rack Inserts for 1,5 ml and 2,0 ml tubes    
640-1200-01  15 ml Tube Rack (for up to 24 x 15 ml tubes)
640-1200-02  50 ml Tube Rack (for up to 8 x 50 ml tubes)
640-1201-01  Pipette Tip Rack
  • further racks availible --> please contact us
for further information see p.3 of the ARI product range (PDF)

"Scorpion"  for Chemistry

Applications:
  • High-Throughput Experimentation
  • Reaction optimization
  • Reaction miniaturization to screen conditions without wasting precious samples
  • Long term scheduled reaction sampling for kinetic assays
  • High-Throughput screening of ligands or substrates for reactions
  • Preparation of LC-MS samples


Features:
  • The speed and versatility of the Scorpion make it the ideal choice for synthetic chemists to automate High-Throughput Experimentation
  • 10-fold increase or more in the number of experiments that can be set up versus a manual workflow
  • Small footprint fits into standard sized fume hoods
  • Enclosed workspace and airflow system allow for an inert atmosphere to be created which makes it possible to use sensitive reagents with confidence
  • Liquid level sensing allows the tip to follow liquid levels improving aspirate and dispense accuracies
  • Single channel head and optimized dispense modes make it easy to work with a wide range of solutions
  • Intuitive and user friendly software makes setting up complex experiments a simple task
  • The open design of the workspace and powerful software allow the system to be configured for virtually any type of labware
  • The single channel head design allows the Scorpion to access any type of tube, vial or plate
  • Optional heater/stirrer system available which allows to place a choice of heating blocks achieving a maximum temperature of approx. 300 °C and stirring speeds of 50 to 1.500 rpm
  • The deck has up to 6 positions and can accommodate 96 racked 15 ml tubes, 24 racked 50 ml tubes, glass vials, deep well blocks or other microwell plates in SBS-format, as well as tip racks
  • The Scorpion makes your work safer and limits lab personnel exposure to solvents
  • Multiple tip sizes can be used in one protocol
    Suitable pipette tips: see separate price list
  • Environment: 4 °C to 70 °C, non condensing
  • Dimensions (w x h x d): 48.3 cm x 69.8 cm x 48.3 cm

"Gryphon" 
Modular Microdispenser System
– "Crystal Gryphon"
– "Gryphon LCP"
– "Crystal Gryphon LCP"

“Gryphon” general features:
  • No disposables, cutting operating costs
  • The “All-In-One” Microdispenser enables screen and protein drop-setting in one protocol
  • Modular design allows for custom set-ups
  • Versatile and upgradeable
  • Add a nano or LCP dispenser at any point in the future
  • Set up sitting and hanging drop vapour diffusion crystallization experiments
  • Set up batch crystallization drops (under oil)
  • Combines individual precipitant and protein solutions into crystallization trial wells
  • X-Y stage with two plate positions and one wash station
  • Low maintenance

96 Syringe Head*:
  • 96 flexible Nitinol needles (memory metal)
  • Dispensing accurately 100 nl to 100 µl volume with a CV of less than 5 %
  • Aspiration from different deep well blocks
    (e. g. 1 ml and 2 ml)
  • Aspiration from reservoir wells into crystallization wells of one crystallization plate
  • 96 head is suitable for further volume options such as
    250 µl, 500 µl or 1000 µl
  • For dispensing buffers and additives
  • *24-syringe head and 384-syringe head are further options


Compatibility with Plates:
  • Suitable for work with deep well, 96-, 384- and 1536-well plates
  • Compatible with most crystallization plates with up to 5 crystallization wells and one reservoir well
  • Commonly used plates from several companies will be included in the software
    (ARI Intelli-Plates, Greiner, Swissci MRC, Corning, Molecular Dimension)
  • Further plate definitions can be added in the software


Nano Protein Dispense Head (optional):
  • Non-contact nano dispenser for dispensing proteins
  • Dispenses 50 nl up to 100 µl with a CV of less than 5 %
    (1-, 2- or 3-channels possible)
  • Two options to aspirate/dispense: Air backed and liquid backed
  • Sample recovery possible to minimize total consumption of protein solutions



LCP (Lipidic Cubic Phase) module (optional):
  • Seeding and for highly viscous samples
  • Syringe based lipidic cubic phase, bicelle dispenser
  • Lipidic sponge-phase screen for membrane proteins
  • Dispenses 25 nl of viscous solutions with a CV < 5%
  • Integrated LCP mixing station
  • Quick change syringe design makes loading the syringe easy
  • Self-aligning syringe needle eliminates the need for constant calibration
  • Aspirate from 0.2 ml tubes with an optionally added longer needle
  • 8 tube positions for seeding applications
  • 96-well sandwich plate ready to seal in less than 2 minutes

"Crystal Phoenix"

General features:

  • No disposables, cutting operating costs
  • Designed to meet requirements of protein crystallography, high-throughput screening and genomics laboratories
  • Nine assay positions: 6 source or destination plate positions, 2 reagent positions,1 wash station position
  • Windows-based drag-and-drop software
  • Closed-loop motion control on each axis: verification of task completion via encoders on each motor
  • Integrated wash-system with computer controlled peristaltic pumps and wash reservoirs for the 96-syringe head as well as the nano dispenser
  • User-friendly software enables real-time protocol validation
  • Software has an integrated predefined plate library containing most commonly used microplates
  • New plates can be added easily to the software

         96-head Dispenser:
  • 96- or 384-channel positive displacement syringe heads with flexible Nitinol-needles
  • Head volumes of 100, 250, 500, 1000 µl available
  • Dispense head can be exchanged easily within minutes for servicing
  • Dispense volumes down to 100 nl with a CV < 5 %

         Single Channel Dispenser:
  • Optional non-contact nano-dispenser drive: can accommodate 1, 2, 3, or 4 channels to deliver volumes as low as 50 nl with a CV < 5 %
  • For set-up of sitting drops, hanging drops and microbatch reactions
  • < 50 sec. to dispense protein and screen to the small wells or hanging drop seals
  • The speed of dispensing the screen and protein eliminates the problem of evaporation even when dispensing as little as 100 nl
  • Gradient dispensing possible
  • Nano dispenser can dispense viscous liquids up to 30 % glycol or 20 % PEG4000

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Hood and Trolley for Robotic Systems

• Panels and doors manufactured in clear plastic

• Aluminium frame

• Opening with rubber cover Ø 80 mm (right) for cables

• Front with door and extra reach-through opening

• Suitable for all robotic systems which require
    a constant humidity (see below for measurements)

• Hood suitable for Single-channel Phoenix and all modular            Gryphon robots from Art Robbins Instruments 

• Inclusive:
- Ultra-sonic humidifier
- Humidity controller
- Humidity sensor


• Optional:
Trolley: 4 locking castors, base plate and 2 shelves 

• Slight design changes possible


"Phoenix"
 for the Chemical Research Laboratory

Fields of application:
  • Biofuel research
  • Bacterial metabolic engineering
  • Biocatalyst development
  • Enzyme optimization

Features:
  • No disposables, cutting operating costs
  • Ideal dispensing system to work with organic solvents such as Methyl Isobutyl Ketone (MIBK) and Butyl Acetate
  • Glass, stainless steel and a fluoropolymer are the only wettable surfaces
  • 96 head compatible with all commonly used chemicals
  • (contact us for further information)
  • Chemically resistant deck
  • Capacity for six blocks and/or tube racks plus three wash positions
  • Compact size allows to place the system in a fume hood
  • Closed-loop motion control on each axis: verification of task completion via encoders on each motor
  • Integrated wash-system with computer controlled peristaltic pumps and wash reservoirs
  • Windows-based drag-and-drop software
  • Choice of 96-head with 1 ml TCSS, widebore TCSS, or flexible needles (please contact us for more information)
  • Dispense head can be exchanged easily within minutes for servicing
  • Dispense volumes down to 1 µl with a CV < 5 %

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"Cobra" - 1- or 4-Channel Nano Dispenser

  • Ideal for preparation of PCR Master Mixes, biochemical assays and drug development
  • Low dead volume minimizes waste
  • Fast non-contact dispensing into 96-, 384- and even   1536-well plates, deep well blocks and PCR plates
  • Suitable for dispensing cells into Terasaki plates          (only 1-Channel Cobra) 
  • Can be used for "Crossmatching" in HLA-laboratories and hospitals
  • Holds full-skirt and semi-skirted PCR plate adapters
  • Dispense 300 nl to 5 ml using 1 or 4 non-contact nano-dispensers
  • Dispense any volume, any well with up to 4 independent reagents in the same pass
  • Dispense gradients for direct dilutions
  • Easy-to-use, computer controlled and Windows based software
  • Mixed modes in one run are possible (switch between aspirate/dispense and bulk dispense)
  • Aspirate from deep well blocks, 0.2 ml and 1 ml or 2 ml tubes
  • 2 position plate deck
  • Liquid level sensing for all reagent bottles
  • Can be integrated into automatic systems for storage of plates --> please ask for further information
  • Integrated wash system

"CrysCam™"

Digital Microscope for Protein Crystal Observation and Documentation
The CrysCam™ Digital Microscope allows you to capture the images of an entire plate with a click of the mouse. The stage and easy-to-use software automatically capture the image of each well and then moves to the next. With the small footprint, the device fits into a small space and can also be set up in a cold room. The CrysCam™ can be used to see crystals during crystallization, instead of looking through a microscope. The high resolution and precise X-Y stage easily mounts to the CrysCam™ base.

CrysCam™ features
  • Compatible with 96-well, 24-well Linbro and Terasaki plates (adapters available) 
  • Reads a 96-well plate in less than three minutes
  • Can be used in a cold room at 4 °C
  • Quality par focal zoom lens with iris
  • Integrated cross polarization
  • 6.5 x zoom with 3.87 mm x 5.16 mm - 0.6 mm x 0.8 mm field of view
  • 3 Mpix CMOS, 8.38 mm sensor USB cameras
  • Modular and upgradeable components
  • Smooth large base platform with integrated LED lighting
  • Image acquisition and processing software
  • Easy-to-use Windows software (Windows.NET)
  • Integrated scoring database for analysis of score in the software
  • Accurate and precise closed-loop control system
  • Predefined plate library makes choosing the right well location quick and easy
  • Stage resolution down to 0.0033 mm
  • Size: (w x h x d) 44.45 cm x 33.02 cm x 34.29 cm, 10.66 kg
  • Users can upgrade their system to a CrysCamplus

 "CrysCamplus"

Digital Microscope for Protein Crystal Observation and Documentation
"CrysCamplus" features:
  • Modular customized configurations
  • Available with 1 or 2 objectives: 5 x, 10 x, 15 x
  • View both visual and UV-images for any well side-by-side
  • Monochromatic 6 Mpix camera
  • Compatible with polarization and fluorophores such as CY3 and GFP
  • Score and compare wells of interest
  • Compatible with all SBS format plates, LCP slides, Linbro, and VDX plates
  • Can be placed in a cold room
  • Any existing CrysCam™ can be upgraded to a CrysCamplus
  • The software makes it quick and easy to compare UV and visible images or sets of images taken on different days
  • The magnification and position of the well in each viewing window can be synchronized for easy comparison
  • Multi-seat software licenses allow all users to view images from any computer

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"CrysCamUV™"
 (and plate incubators)

Protein crystallization imaging system with UV and visible light
and options for working with fluorophores
  • Automatically scan the plate and capture visual and UV images and save for review at any time
  • Scan multiple wells in one run, possible to scan sub-wells
  • View both visual and UV image for any well side-by-side
  • Capture images with two different wavelengths in the
    UV-spectrum: 334 nm and 365 nm
  • Create a workflow and image several light sources in one protocol e. g. visible light, UV-light, Texas Red and 
    cross-polarization
  • The CrysCamUV™ can be used to capture crystal images in nano size drops
  • Ability to capture multiple slices and create a highly detailed image of the complete drop
  • Powered focus and zoom through the software control
  • Score and compare wells of interest
  • Software offers integrated database for analysis and score
  • Parfocal lens remains focused when zooming
  • Artemis VS60 camera with a resolution of 2750 x 2205 (6.0 MPix)
  • Digital image of 2.37 microns/pixel with a minimum zoom to 0.7 microns/pixel
  • Can flag wells of interest
  • Can view individual wells and sub-wells with or without a polarizer
  • Compatible with all plates in SBS-sized format and Linbro plates
  • Determine crystal X-Y-Z position for use with in-situ crystal diffraction
  • Filter removes UV reflections from plates
  • Integrated cooling function can set temperature for the camera down to -10 °C to get better images
  • Enclosure covers lens and plates to block stray light
  • Customized filter options for working with fluorophores available e. g. Texas Red  
  • Optional cooling version to keep plates that have been stored in the refrigerator cool while imaging
  • Plate hotels for 42, 210 and 504 plates available --> please enquire.  

Refurbished "Hydras"

Art Robbins Instruments continues to offer the entire product line of "Refurbished Hydras" to offer you high-speed aspiration and dispension of certain volumes at a low price. The "refurbished Hydras" are overhauled, inspected, assembled, tested and tested by the same engineering team that originally designed and manufactured these devices. All syringes are revised and brought in mint condition. For all "refurbished devices" the warranty is one year.
"Refurbished Hydras" features:
  • 384 or 96 syringes
  • Equipped with or without washing module
  • Equipped with or without plate positioner
  • Syringe size of 100 μl, 290 μl, 580 μl or 1 ml
  • Syringes made of flexible Nitinol or PTFE-coated steel

LCP Mixing Station

The LCP (lipidic cubic phase) Mixing Station is ideally suited for the mixing of viscous solutions often used for the crystallization of membrane proteins.
Features:
  • Suitable for various types of syringes such as from Hamilton or Art Robbins Instruments
  • Each volume can be mixed as long as both syringes have the same loading volume
  • Prevents variations over several days or those that can occur by different users
  • Last mixing time is shown on the display
  • Easy and fast to load
  • By loading the syringe, the mixing parameters are automatically adjusted so that the volume to be mixed corresponds to the sample volume in the syringe
  • Acoustic alarm signal can be set automatically after entering the time
  • Easy to clean mixing chamber made of stainless steel
  • Compact size (w x h x d): 34.3 cm x 13.9 cm x 11.4 cm
  • Choice of syringes available

LCP Hand-Held Multi Volume Dispenser

The LCP Hand-Held Dispenser can be used with syringes from different manufacturers such as Art Robbins Instruments or Hamilton.

The Hand-Held Dispenser allows setting up to 200 steps and can move 1, 2 or 3 steps per click. The volume of the syringe can be divided into 50, 100 or 200 steps per dispense, e. g. for 10 µl the dispense volume can be set to 50 nl, 100 nl or 200 nl.

LCP Mixer/Dispenser - Starter Kit

Get the LCP Mixing Station and the Hand-Held Multi Volume Dispenser together with useful accessories as a kit.
Parts included in the starter kit:

  • 1 x LCP Mixing Station
  • 1 x LCP Hand-Held Multi Volume Dispenser
  • 1 x 10 µl Syringe plus 3 x Needles
  • 2 x 100 µl Syringe
  • 1 x LCP Coupling and Ferrule Mix, ARI-ARI syringe
  • 1 x LCP Coupling and Ferrule Mix, ARI-Hamilton syringe

AutoScope
Customized product to score Terasaki plates on Microscopes

"AutoScope” features:
  • Secure handling of Terasaki plates on different microscopes.
--> We also offer suitable Terasaki plates. 
  • Automatically advances Terasaki plate on your microscope as the scores for each well are entered.
  • Stage movement to any well of the plate with one click of the mouse. 
  • Stage is controlled by the SystemLink HistoScope software (see below).
  • Stages are available for CK2, IX2-SP, and IMT-2 microscope from Olympus and Ts2R from Nikon Eclipse.
  • Customized stages for other microscopes are possible.

“HistoScope” features:
  • Microsoft Windows-based software operating the automated microscope stage in clinical Histocompatibility laboratories.
  • Microscope workstation can be networked to review scores at your desk. 
  • Two software versions for SQL-servers or local computers (Access-based) are available.
  • Patient and donor database with search tools included.
  • Efficient movement of the motorized stage, using the controller keypad or the computer keyboard.
  • Score, re-score and double-score features available.
  • Archive and restore functions for trays and scores in the software.
  • Patient sample search tool enables easy loading of screening crossmatch trays.
  • Import/Export function allows sharing tray definitions with other HistoScope software users.

Automatic Typing Tray Oiler
for HLA laboratories

  • Equipped with a head with stainless steel pins
  • Head moves into a self-filling reservoir of oil and then automatically moves and touches the wall of the typing tray wells delivering the oil
  • Predetermined volume of oil is dispensed into all wells of a typing tray in one step
  • Volumes between 1 µl and 15 µl can be selected through the depth that the pins penetrate the oil (min. and max. volume depends on the oil used)
  • Easy operation through a switch in the front of the device
  • A removable clear acrylic cover protects the oil reservoir from contamination with dust
  • Operation in continuous mode is possible, dispensing oil every six seconds automatically
  • Interchangeable heads for 60, 72 and 96 well trays are available    --> Terasaki plates are also available from us
  • Heads are easily changed without tools by releasing two knurled screws

Single and multiple (six and eight)
hand-held Syringe Dispensers

  • Designed to simplify the multiple liquid handling steps in serological tests
  • Single, six and eight precision glass syringes in a hand-held, push button repeating dispensing mechanism
  • Less than 1 % variation between the single syringes
  • Syringe plungers with PTFE tips. Replacement syringes and plungers are available
  • Syringe volumes from 25 µl to 500 µl
  • Graduated to deliver 1/50 of the total volume
  • All hand-held dispensers are also available with shooting needle

Tissue typing single Microsyringes
and Repeating Dispensers

  • Coated stainless steel syringes (fixed, inflexible)
  • „Soft-drop“, wide syringes, hanging drops by dispensing
  • „Shooting“, narrow syringes, drop-dispensing by pressure
  • 50 step repeating dispenser

Cell Microsyringes and Repeating Dispensers

  • 80 step repeating dispenser
  • For filling 60-well or 72-well Terasaki plates

Stream Splitter

  • For 36-, 60-, 72- and 96-well plates
  • Among other things suitable for oil, eosin or formalin
  • Four dispenser heads available: 6, 8, 10 or 12 needles
  • Suitable fittings for connection to the dispenser
  • Autoclavable

“Complement Cooling System” and accessories

  • Cooling system for 6 x 10 ml complement trays
  • For work without ice bath
  • Reusable cooling block with refreezable coolant
  • Keeps a temperature of less than 5 ° C for over an hour
Further products von Art Robbins Instruments:



12-2023
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