Single-cell genomics technologies have advanced to a point that allows profound insights into tissues with high resolution enabling studies across multiple individuals at the same time. Whether samples are analysed by scRNA-seq, ATAC-seq, snRNA-Seq, CITE-Seq or other ‘omics applications, one of the most important factors for data quality and thereby key to meaningful data, is sample quality. Results should be reproducible, and cells and nuclei isolated as quickly and efficient as possible to ensure high viability and yield. Finding the ideal protocol, as well as skilful hands, is a difficult task and can take a lot of time and effort.

The Singulator™ system by S2 Genomics, available from Dunn Labortechnik, simplifies tissue dissociations into single-cell suspensions and nuclei suspensions to the press of a button, reducing variability due to handling, and shortening isolation times to 6 – 80 minutes.